Abstract Ischemic heart disease is a major global cause of morbidity and premature death and guidelines for diagnosis and treatment are predominantly shaped by the atherosclerotic plaque burden of epicardial coronary artery disease (CAD). However, recent studies have reported the diverse spectra and etiopathogenesis of chronic CAD, including in addition to atherosclerosis, coronary vasculature disorders, such as microvascular and vasospastic angina. Ischemia without obstructive CAD is increasingly recognized and can be caused by transient and/or sustained damage in myocardial perfusion, […]
